Cholesterol biosynthesis inhibitors, which were actually put into clinical use more than 20 years ago, have been discontinued with side effects. 1976 by Endo and other people in Japan in the extract of Orange Penicillium (penicilliumcitrinum) found in the United States of America (Mevastatin, formerly known as Compactin), also called the United States tile stop. Other researchers have shown that it has a significant effect on reducing the level of serum TC in both animals and hypercholesterolemia patients. It was rumored in Japan that it could change the morphology of the small intestine in the dog and stop the clinical application. Subsequently, Lovastatin was obtained from soil-soil koji fungus culture medium in the United States (Lovastatin formerly known as Mevinolin), and Leva stopped and beauty descending. Extensive studies in North America, Western Europe, Australia and Japan confirmed that it is a-reductase inhibitor that can safely and effectively reduce serum TC levels in patients with hypercholesterolemia and was approved by the U.S. Food and Drug Administration in 1987 for clinical use. Simvastatin (Simvastatin, formerly known as synvino1in), also named Ceiba stop, Shu and descending; and Pravastatin (Pravastatin, formerly known as CS514 and SQ31000), Powwow stop, pravastatin, American hundred Le Town, they are the basis of the United States and the methylation of the derivatives. Another kind of fluvastatin (Beta-uvastatin, formerly known as SRI-62320) and the other type of simvastatin (Atorvastatin, Lipitor). It is expected that new inhibitors of-reductase will continue to emerge.