Clinical Application Of-reductase Inhibitor

- Jul 12, 2017-

The effect of cholic acid on TC is recognized, but it is difficult for patients to insist on taking it for a long time because of side effects. Although the taste of cholic acid is improved, some side effects can be overcome, but they can only prevent bile acid and cholesterol from the intestinal absorption, cholesterol in vivo synthesis without inhibition, and most hypercholesterolemia patients, blood TC mainly from the body synthesis. Therefore, the bile acid integration agent alone can not achieve the ideal effect. The found 3-hydroxy-methyl-amyl coenzyme A (-) reductase inhibitor can inhibit the biosynthesis of cholesterol.