Which drug-resistant patients need tenofovir rescue?
Lamivudine resistance such as changing entecavir, because of its cross-resistance, need 2 tablets a day, more than 6 months there is still the risk of drug resistance. Addition of adefovir due to its lower efficacy, higher levels of the virus may occur in patients with dual resistance. Tenofovir is therefore the best choice, may be effective in the first plus adefovir ineffective.
In combination with lamivudine-resistant 加阿德福韦 invalid cases, due to lack of efficacy of adefovir, or have been resistant to switch to tenofovir monotherapy relief, viral levels can be decreased, but not Can work. A group of such cases 59 cases 20 cases resistant to LMV, ADV resistance 17 cases before dressing median HBV DNA5.33 log10IU / ml, during 48 weeks and 96 weeks hypersensitivity examination, virus consistently below 80cp / ml, respectively, only 46% and 64%.
Tenofovir and entecavir are used in combination to rescue multidrug resistance treated with multiline nucleosides. A group of 57 patients who had used a variety of drugs called nucleoside in four years, nearly half of decompensated liver disease or cirrhosis, such patients often promote drug sicker, or even catastrophic consequences. Combined treatment of two drugs, 90% within 6 months of HBV DNA <400 cp / ml, effective against the complex resistance.