What are the adverse reactions of tenofovir?

- Nov 25, 2017 -

What are the adverse reactions of tenofovir?

 

7% of patients treated with tenofovir also had elevated creatine kinase and had not seen myosis. Tenofovir also has less nephrotoxicity and can be reduced from renal clearance to tubular defects, which are rare. Many people read the past instructions on the nephrotoxicity of tenofovir, such as can cause diabetes, calcium and phosphorus loss of bone disease and so on, but that occurred in AIDS patients.

 

Nephrotoxicity in patients with chronic hepatitis B or cirrhosis is very mild, clinical trials up to 5 years, no significant renal damage; foreign listed more than five years, there is no report in this regard.

 

Conventional kidney function is detected glomerular damage. The toxicity of adefovir and tenofovir is a damage to the tubules. Damage to the tubules makes some useful substances filtered out from the glomerulus, which should have been absorbed in the tubules but not absorbed, but excreted from the urine . This is different from routine renal examinations: serum creatinine does not necessarily increase; serum uric acid does not increase but decreases; phosphorus should also be reduced, but not necessarily influenced by food and metabolism; may most likely reflect renal tubular toxicity The method is to collect 24h urine to check for β2 microglobulin reduction.