Tenofovir treatment of compensatory cirrhosis effect?
Antiviral therapy may prevent the progression of the disease; there have been many reports that if the treatment is effective, it will reverse the liver fibrosis, but lamivudine and adefovir have weak drug resistance and multi-drug resistance, the treatment is too long and the restriction is limited Its anti-fibrosis effect.
The recent medical journal Lancet, the UK's highest impact factor, reported that long-term tenofovir treatment led to more pronounced remission of liver fibrosis. HBeAg (+) and (-) were enrolled in a large group of patients with tenofovir and adefovir randomized double-blind control treatment for 1 year, continue to open with tenofovir to 5 years, based on HBV DNA inhibition, ALT Reduce and HBeAg negative, and Knodell inflammation score decreased at the same time, only the reversal of liver fibrosis. A total of 348 liver biopsy samples were obtained before treatment, 1 year and 5 years. Of the 96 patients with liver cirrhosis (fibrosis score 5-6 points), 96 cases were reduced by at least 2 points in 1 case and at least 3 cases were reduced in 56 cases. reverse.