HIV Integrase Inhibitor Elvitegravir CAS 697761-98-1

- Aug 29, 2017-

Basic Info

Product Description

  • Model NO.: APIA2

  • Purity: 99% Min

  • Trademark: ChinWon

  • Origin: Xi′an

  • Characteristics: Anti-Virus

  • Appearance: White Crystalline Powder

  • Specification: 99%

Product Name: Elvitegravir 
CAS NO.: 697761-98-1
Quality Standard: USP32/BP2007/EP7

Elvitegravir (EVG; JTK-303; GS-9137) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. Elvitegravir is a human immunodeficiency virus integrase inhibitor with EC50 of 0.7, 2.8 and 1.4 for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD. 
Elvitegravir (also known as GS-9137 or JTK-303), a monoketo acid modified from the distinct diketo acid moiety (DKA) motif, is a potent inhibitor of human immunodeficiency virus type I (HIV-1) integrase, an enzyme integrating the viral DNA into the cellular DNA of the host during HIV replication. Elvitegravir inhibits the function of HIV-1 integrase through blocking viral DNA strand transfer and integration, which prevents the replication of HIV and subsequently allows viral DNA to be metabolized by cellular enzymes. Multiple studies indicate that elvitegravir not only inhibits the replication of a variety of subtypes of HIV-1 but also exhibits antiviral activity against murine leukemia virus (MLV) and simian immunodeficirncy virus (SIV). 

Used to Anti-AIDS

CAS No.:330600-85-6
Content:≥ 99.00%
Appearance:white,Crystalline Powder or colorless crystal
Molecular Weight328.4072 
Loss on Drying:≤0.2%
Residue on ignition:≤0.1%
Heavy Metals:≤10PPM
Acidity or Alkalinity:Conform
Readily Carbonizable Substances:Conform
Ordinary Impurities:Conform