Entecavir PK Tenofovir, who is the real king?
Hepatitis B patients often ask me: Dr Wang, entecavir and tenofovir, who better? Both entecavir and tenofovir are the first-line antivirals recommended by major hepatitis B guidelines in the world. Personally, I think it is better for both types of hepatitis B patients to say who is better.
Entecavir with little resistance, with few adverse reactions, the most prominent advantage is the long-term use of safety is very good. The weaknesses of entecavir compared to tenofovir lie in: 1, the antiviral effect is not as strong as tenofovir; 2, there is cross-resistance with lamivudine and telbivudine, and if lamivudine or Bifidin resistant experience, you can no longer use single entecavir; 3, can not be used for pregnant women.
If only from the strength of the anti-virus point of view, Tenofovir is the real king! It is the most potent anti-hepatitis B virus drug known to mankind. Since it was launched in 2008, it has kept an unbeaten record in the fight against hepatitis B virus with zero resistance rate. ! Tenofovir's outstanding advantage is the strongest antiviral effect, zero resistance rate. Tenofovir can take almost all resistant hepatitis B virus and can also be used in pregnant women. The only concern with tenofovir is the risk of developing kidney damage. Long-term use of tenofovir may increase the risk of kidney damage in older patients with underlying kidney disease, diabetes, and hypertension.
Need to be pregnant, with tenofovir, usually to maintain treatment with entecavir; patients with underlying kidney disease or concurrent high blood pressure, diabetes, hepatitis B patients, as first choice of entecavir; past lamivudine or telbivudine resistant patients , Should be the preferred tenofovir; use of hormones or chemotherapy drugs, worried about entecavir resistance, you can switch to tenofovir for a short time, hormone or chemotherapy drugs, you can exchange entecavir.
Entecavir and tenofovir are all human anti-hepatitis B virus drugs, the so-called Chunlan Chrysanthemum, all good at victory, the key is the rational use of flexible use.