Clinical application of Probucol

- Jul 12, 2017 -

Probucol also known as propofol. The drug absorbs less than 10% after oral administration, such as with food, and can get a higher blood concentration. 3-4 months of continuous medication, blood concentration gradually increased, and then gradually stabilized. The effect of blood lipid lowering was not closely related to plasma concentration. It has been suggested that the drug inhibits the synthesis of apob, which reduces LDL production, and because it promotes the decomposition of the LDL and promotes the blood cholesterol into the bile with feces. Combined with these effects, the level of LDL and TC decreased in the blood. Because the drug can inhibit the synthesis of apoai, the blood HDL level is reduced. The drug regulates the intensity of lipid and the individual difference is larger. After Probucol, the level of serum 10l-c decreased, but the progression of atherosclerosis was promoted. During the medication, the patient's belly yellow tumor and skin yellow tumor can be seen subsided. In addition, Probucol is a strong antioxidant that helps to inhibit the formation and development of atherosclerosis.