Nicotinic acid (Nicotinicacid, also known as niacin) is a B-group of vitamins. When dosage is more than the dose of vitamin, it can obviously regulate the blood lipids. The chemical structure of nicotinic acid is: nicotinic acid is easy to absorb from gastrointestinal tract, the blood concentration of 30-60 minutes after oral dose reaches the peak, it is widely distributed in organism tissue, and its half-life is about 45 minutes. Metabolize in the liver. In High-dose oral administration, the main metabolites were niacin (nicotiuricacid), N-methyl nicotinamide and 2-pyridine derivatives. 2/3 is discharged from the urine in constant form. The main mechanism of nicotinic acid regulating blood lipids is to inhibit the formation of camp, which leads to the decrease of triglyceride activity, the decrease of lipid hydrolysis in adipose tissue, the decline of the concentration of NEFA fatty acid (VLDL), the decrease of the liver synthesis, and the decrease of IDL and LDL. In addition, nicotinic acid can be used to synthesize nicotinic acid with glycine under the action of Coenzyme A (COA), which prevents hepatocytes from using COA to synthesize cholesterol. The mechanism of HDL level elevation in blood is unknown.
Clinical application of nicotinic acid and its derivatives
- Jul 12, 2017 -